This is a little humorous, but vitally important to get into your thick writing heads: ignoring the submission guidelines is like turning up to a job interview in your underpants (ie. there are very few markets that will tolerate it). Jessica Bell makes 15 points, some of which are sweary, and ends with:
Next time, just remember, you are emailing a person, not a robot, and guidelines are there for a reason. They're there to ensure everything is done in a time-efficient manner. I want to spend time reading your wonderful work, not wasting time trying to make up for your laziness. If you were in my shoes, I think you would feel this way too.
Remember people: RtFG (Read the Friendly Guidelines). I can't stress this enough (which is why this is like the third article I've posted touching on it). It speaks to professionalism, and it helps keep you in the reading pile, which is the best you can hope for.